A cyclic AMP-regulated negative feedforward system for neuritogenesis revealed in a neuroblastoma x glioma hybrid cell line

Authors
Citation
T. Tojima et E. Ito, A cyclic AMP-regulated negative feedforward system for neuritogenesis revealed in a neuroblastoma x glioma hybrid cell line, NEUROSCIENC, 104(2), 2001, pp. 583-591
Citations number
39
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROSCIENCE
ISSN journal
03064522 → ACNP
Volume
104
Issue
2
Year of publication
2001
Pages
583 - 591
Database
ISI
SICI code
0306-4522(2001)104:2<583:ACANFS>2.0.ZU;2-K
Abstract
We examined the role of second messengers during the neuritogenesis that ac companies neuronal differentiation in a neuroblastoma x glioma hybrid cell line (NG108-15). NG108-15 cells extended neurites after treatment with dibu tyryl cyclic AMP. This dibutyryl cyclic AMP treatment evoked the synthesis of voltage-dependent Ca2+ channel proteins in the cells. The number of neur ites was decreased by Ca2+ influx under condition of high K+. Interestingly , the increase of neurites stimulated by dibutyryl cyclic AMP and the decre ase of neurites caused by high K+ were both reversible. This is the first study to demonstrate that cyclic AMP regulates a negative feedforward system for neuritogenesis, which links with Ca2+ signaling. Su ch a dual role of cyclic AMP may play an important part in precise neurite targeting. (C) 2001 IBRO. Published by Elsevier Science Ltd. All rights res erved.