Immediate post-transplant nephrosis in a patient with congenital nephroticsyndrome

A 19-month-old girl with congenital nephrotic syndrome of the Finnish type underwent a living-related renal transplant; 24 h after transplantation she became massively nephrotic. She did not respond to steroids, plasmapheresi s, and high-dose cyclosporine. A month later, a renal biopsy showed only gl omerular foot process effacement. She was treated with high-dose methylpred nisolone pulses and oral cyclophosphamide. She rapidly went into complete r emission with no further relapses. Graft function has been stable 2 years a fter transplantation.