Acquired glomerulocystic kidney disease following hemolytic uremic syndrome

Glomerulocystic kidney disease (GCKD) is a rare congenital condition that i s usually reported in infants and young children. Only five cases of acquir ed GCKD after an acquired renal disease have been reported. Among these, tw o patients have developed cystic glomerular lesions following hemolytic ure mic syndrome (HUS). We report a third case in a 2-year-old patient with thi s association. Common features between these three cases include atypical H US, development of GCKD after prolonged peritoneal dialysis treatment, seve re hypertension, and normal-sized kidneys without development of macroscopi c cysts. Pathology findings in our patient include heavy expression of epid ermal growth factor receptor in proximal tubules and evidence of obstructio n of the glomerular outflow. We speculate that cystic dilatation of the Bow man's capsule may be secondary to ischemic lesions leading to proximal tubu lar obstruction.