Almost 2 decades ago, it was pointed out that physical therapists tended to
overlook the tenuous nature of the scientific basis for the use of therape
utic ultrasound. The purpose of this review is to examine the literature re
garding the biophysical effects of therapeutic ultrasound to determine whet
her these effects may be considered sufficient to provide a reason (biologi
cal rationale) for the use of insonation for the treatment of people with p
ain and soft tissue injury. This review does not discuss articles that exam
ined the clinical usefulness of ultrasound (see article by Robertson and Ba
ker titled "A Review of Therapeutic Ultrasound: Effectiveness Studies" in t
his issue). The frequently described biophysical effects of ultrasound eith
er do not occur in vivo under therapeutic conditions or have not been prove
n to have a clinical effect under these conditions. This review reveals tha
t there is currently insufficient biophysical. evidence to provide a scient
ific foundation for the clinical use of therapeutic ultrasound for the trea
tment of people with pain and soft tissue injury.