Costunolide, a sesquiterpene from the stem bark of Magnolia sieboldii, inhibits the RAS-farnesyl-proteintransferase

Authors
Park, SH Choi, SU Lee, CO Yoo, SE Yoon, SK Kim, YK Ryu, SY
Citation
Sh. Park et al., Costunolide, a sesquiterpene from the stem bark of Magnolia sieboldii, inhibits the RAS-farnesyl-proteintransferase, PLANTA MED, 67(4), 2001, pp. 358-359
Citations number
12
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PLANTA MEDICA
ISSN journal
00320943 → ACNP
Volume
67
Issue
4
Year of publication
2001
Pages
358 - 359
Database
ISI
SICI code
0032-0943(200106)67:4<358:CASFTS>2.0.ZU;2-M
Abstract
Costunolide, a germacrane sesquiterpene lactone isolated from the stem bark of Magnolia sieboldii demonstrated a significant inhibition upon the farne sylation process of human lamin-B by farnesyl-proteintransferase (FPTase), in a dose dependent manner in vitro (IC50 value was calculated as 20 muM). It was also found to exhibit an inhibition upon the proliferation of cultur ed human tumor cells, i.e., A549 (non small cell lung), SK-OV-3 (ovary), SK -MEL-2 (melanoma), XF498 (central nerve system) and HCT-15 (colon), in vitr o.