1-O-galloyl-6-O-(4-hydroxy-3,5-dimethoxy)benzoyl-beta-D-glucose, a new hepatoprotective constituent from Combretum quadrangulare

Authors
Adnyana, IK Tezuka, Y Awale, S Banskota, AH Tran, KQ Kadota, S
Citation
Ik. Adnyana et al., 1-O-galloyl-6-O-(4-hydroxy-3,5-dimethoxy)benzoyl-beta-D-glucose, a new hepatoprotective constituent from Combretum quadrangulare, PLANTA MED, 67(4), 2001, pp. 370-371
Citations number
9
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PLANTA MEDICA
ISSN journal
00320943 → ACNP
Volume
67
Issue
4
Year of publication
2001
Pages
370 - 371
Database
ISI
SICI code
0032-0943(200106)67:4<370:1ANH>2.0.ZU;2-#
Abstract
A new gallic acid derivative, 1-O-galloyl -6-O-(4-hydroxy-3,5-dimethoxy)ben zoyl-beta -D-glucose (1) has been isolated from an H2O-fraction of MeOH ext ract of Combretum quadrongulare seeds. Compound 1 exhibited potent hepatopr otective activity against D-GalN/TNF-alpha -induced cell death in primary c ultured mouse hepatocytes with an IC50 of 3.3 muM.