Background: The aim of the study was to investigate psychological and physi
ological responses of bulimic patients to the repeated presentation of food
cues. Method: On 2 subsequent days, 48 bulimic women (DSM-IV) were confron
ted with high- or low-caloric food for 20 min. A control group (n = 24) was
exposed to high-caloric food once. Blood sugar levels were manipulated wit
h a glucose load. Results: High-caloric food only elicited increases in urg
e to binge, subjective and physiological stress in the first session. Durin
g the second session, reported urge to binge and subjective stress was sign
ificantly lower. Bulimic patients confronted with high-caloric food showed
higher subjective and physiological stress in the first session compared to
bulimic patients confronted with low-caloric food. In the second session,
they reported more subjective stress and urge to binge, compared to the low
-caloric group. Blood sugar revels did not affect psychological and physiol
ogical responses. Discussion: The results are discussed in terms of the con
ditioning model of binge eating model, habituation models and implications
for exposure therapy. Copyright (C) 2001 S. Karger AG.