Evolutionary expansion of CRIB-containing Cdc42 effector proteins

Citation
Dm. Pirone et al., Evolutionary expansion of CRIB-containing Cdc42 effector proteins, TRENDS GEN, 17(7), 2001, pp. 370-373
Citations number
25
Categorie Soggetti
Molecular Biology & Genetics
Journal title
TRENDS IN GENETICS
ISSN journal
01689525 → ACNP
Volume
17
Issue
7
Year of publication
2001
Pages
370 - 373
Database
ISI
SICI code
0168-9525(200107)17:7<370:EEOCCE>2.0.ZU;2-B
Abstract
Cdc42, a small GTPase, regulates actin polymerization and other signaling p athways through interaction with many different downstream effector protein s. Most of these effector proteins contain a Cdc42-binding domain, called a CRIB domain. Here, we describe the evolutionary analysis of these CRIB-con taining proteins in yeast, worms, flies and humans. The number of CRIB-cont aining effector proteins increases from yeast to humans, involving both an increase within families and the emergence of new families. These evolution ary changes correlate with the development of the more complex signaling pa thways present in higher organisms.