Bjw. Venmans et al., Bronchial intraepithelial neoplastic lesions in head and neck cancer patients: Results of autofluorescence bronchoscopy, ANN OTOL RH, 110(7), 2001, pp. 635-638
To determine the efficacy of autofluorescence bronchoscopy for detection of
bronchial intraepithelial neoplastic lesions in head and neck cancer patie
nts, we analyzed data from head and neck cancer patients who underwent both
white light bronchoscopy and autofluorescence bronchoscopy for the rates o
f detection of intraepithelial neoplastic lesions. The results of the histo
pathologic examination were compared with the bronchoscopic findings. The s
ensitivity for detection of intraepithelial neoplastic lesions was calculat
ed. Eleven moderate dysplasias and 3 severe dysplasias were detected during
8 of the 42 bronchoscopic examinations (19%) in 6 of the 24 patients (25%)
. The sensitivities for white light bronchoscopy alone and for white light
bronchoscopy combined with autofluorescence bronchoscopy for detection of i
ntraepithelial neoplastic lesions were, respectively, 21% (3 of 14) and 57%
(8 of 14). In short, bronchial intraepithelial neoplastic lesions were fou
nd in a considerable percentage of head and neck cancer patients. Use of au
tofluorescence bronchoscopy improved the detection of these lesions.