Potential tuberculostatic agents: Micelle-forming copolymer poly(ethylene glycol)-poly(aspartic acid) prodrug with isoniazid

Authors
Silva, M Lara, AS Leite, CQF Ferreira, EI
Citation
M. Silva et al., Potential tuberculostatic agents: Micelle-forming copolymer poly(ethylene glycol)-poly(aspartic acid) prodrug with isoniazid, ARCH PHARM, 334(6), 2001, pp. 189-193
Citations number
29
Categorie Soggetti
Pharmacology & Toxicology
Journal title
ARCHIV DER PHARMAZIE
ISSN journal
03656233 → ACNP
Volume
334
Issue
6
Year of publication
2001
Pages
189 - 193
Database
ISI
SICI code
0365-6233(200106)334:6<189:PTAMCP>2.0.ZU;2-6
Abstract
With the objective of obtaining slow-acting isoniazid derivatives, of poten tial use as chemoprophylactics or chemotherapeutics in tuberculosis, the mi celle-forming copolymer of poly(ethylene glycol)-poly(aspartic acid) prodru g with isoniazid was synthesized. The derivative obtained was found to be a ctive in Mycobacterium Il(tuberculosis culture, with a minimal inhibitory c oncentration (MIC) 5.6 times lower than that of the tuberculostatic drug.