Background: The unpredictability of the early course of Guillain-Barre synd
rome (GBS) makes it difficult to determine which patients' conditions will:
worsen under observation. Most large randomized treatment trials for GBS h
ave used an inability to walk as the enrollment criterion. Consequently, li
ttle is known about the treatment of those patients with milder degrees of
affection.
Objectives: To determine the approximate frequency of mild GBS with the per
sistent ability to walk and to see if there were features that predicted th
at the illness would remain mild.
Setting: A registry of patients with GBS seen on the wards and in the neuro
logy clinic from January 1, 1992, to May 1, 2000, in a 400-bed community te
aching hospital.
Patients: Twelve (4.7%) of 254 patients in our case series were able to wal
k throughout their illness. Eight had been treated with plasmapheresis or i
ntravenous immunoglobulin; the others were observed without treatment.
Results: There was no age, sex, or seasonal preponderance in comparison wit
h, large case series that included cases of all severities. Nine of 12 pati
ents had a preceding respiratory tract infection, 10 had paresthesias, 7 ha
d prominent pain, and 9 had ataxia. Seven of 10 patients who were examined
had normal cerebrospinal fluid protein levels. It took 8 days, on average,
to reach the maximal degree of weakness. One additional treated patient, ex
cluded from our case series, had mild weakness for the first 3 weeks and su
bsequently worsened with a relapsing course more typical of chronic inflamm
atory demyelinating polyneuropathy. Eleven patients demonstrated proximal,
intermediate, or distal conduction block, and only 3 had a mild degree of d
enervation. There were no distinguishing clinical or electrophysiologic fea
tures between treated and untreated patients with mild GBS and, except for
the mild degree of affection and the absence of substantial electromyograph
ic changes of axonal disruption, there were no important differences betwee
n these mild cases as a group and patients who developed more severe GBS.
Conclusions: Cases of mild GBS reach a clinical nadir in a similar time to
those with more severe disease. Treatment may be unnecessary inpatients who
are able to walk during the second week of illness, but observation until
approximately the eighth day seems appropriate to be certain that the illne
ss does not progress. In all likelihood there are mild cases of GBS that ne
ver come to the attention of a neurologist.