Effect of dietary omega-3 fatty acids on high-density lipoprotein apolipoprotein AI kinetics in type II diabetes mellitus

The effect of a dietary fish oil supplementation on metabolism of HDL was s tudied in type II diabetes mellitus. Endogenous labeling of HDL-apo AI was performed using a 14 h primed infusion of D3-leucine in five diabetic patie nts before and 2 months after treatment with maxEPA(R). Isotopic enrichment curves were analyzed using a monoexponential function. After treatment, pl asma cholesterol level remained unchanged (205.4 +/- 41.9 vs. 206.8 +/- 30. 7 mg/dl, NS), whereas plasma triglycerides were decreased (155.4 +/- 67.9 v s. 202.6 +/- 32.2 mg.dl, P=0.06). Plasma apo AI was similar under maxEPA(R) . (116.0 +/- 25.6 vs. 111.8 +/- 25.4 mg/dl, NS), and HDL-cholesterol and HD L-triglycerides were also not markedly changed (30.2 +/- 10.0 vs. 27.1 +/- 10 mg/dl, and 15.3 +/-9.8 vs. 19.2 +/- 10.4 mg/dl, NS). HDL-apo AI fraction al catabolic rate (FCR) and absolute production rate (APR) were significant ly decreased after treatment with maxEPA(R) (0.27 +/-0.09 vs. 0.37 +/-0.08 pool day, P < 0.05, and 12.1<plus/minus>2.8 vs. 16.1 +/- 3.3 mg/kg per day, P < 0.05). These findings showed an effect of maxEPA(R) on kinetics of apo lipoprotein AI in type II diabetes mellitus, probably linked to changes in plasma triglyceride level. (C) 2001 Elsevier Science Ireland Ltd. All right s reserved.