An economic evaluation of universal infant vaccination against hepatitis avirus using a combination vaccine (HiQ-HepB): a decision analytic approachto cost effectiveness
A. Harris et al., An economic evaluation of universal infant vaccination against hepatitis avirus using a combination vaccine (HiQ-HepB): a decision analytic approachto cost effectiveness, AUS NZ J PU, 25(3), 2001, pp. 222-229
Citations number
23
Categorie Soggetti
Public Health & Health Care Science
Journal title
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PUBLIC HEALTH
Objective: To evaluate the health impact and cost effectiveness of two infa
nt vaccination strategies for protection against hepatitis B virus (HBV) in
fection in the Australian population. Vaccinating only high-risk infants, a
ssuming 65% compliance, was compared with universal vaccination of infants
using a combination Hib-HepB vaccine, with 87.4% compliance.
Method: A Markov model simulated the natural history of HBV infection and d
isease in an Australian birth cohort. The cohort was divided into those at
high risk of infection (infants born into high-risk families) and low-risk
infants. Clinical and epidemiological data used were obtained from publishe
d reports and a survey of clinical experts. The model included the health c
osts associated with acute and chronic HBV infection, and the sequelae of c
hronic HBV infection.
Results: The model predicted that universal hepatitis B vaccination of an A
ustralian birth cohort (260,000 births) would result in a 77% reduction in
cases of HBV infection. The incremental cost per life year gained was $11,8
62, which is low compared with many other health care interventions. With n
o discounting of costs or consequences, universal vaccination with the comb
ination vaccine was predicted to save lives and reduce costs.
Conclusion: There is no socially accepted threshold value for cost per life
year gained to guide decisions about funding Australian health care interv
entions. Nevertheless, based on these results, universal hepatitis B vaccin
ation of Australian infants using a combination Hib-HepB vaccine would almo
st certainly be regarded as a worthwhile investment of public funds.