Novel tricyclic benzothiazolo[2,3-c]thiadiazine antagonists of the platelet ADP receptor (P2Y(12))

Authors
Scarborough, RM Laibelman, AM Clizbe, LA Fretto, LJ Conley, PB Reynolds, EE Sedlock, DM Jantzen, HM
Citation
Rm. Scarborough et al., Novel tricyclic benzothiazolo[2,3-c]thiadiazine antagonists of the platelet ADP receptor (P2Y(12)), BIOORG MED, 11(14), 2001, pp. 1805-1808
Citations number
11
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
14
Year of publication
2001
Pages
1805 - 1808
Database
ISI
SICI code
0960-894X(20010723)11:14<1805:NTBAOT>2.0.ZU;2-R
Abstract
Novel non-nucleoside tricyclic platelet ADP receptor (P2Y(12)) antagonists hat e been discovered that bind reversibly and with high affinity to the pl atelet receptor. Condensation of various 2-aminobenzothiazoles with chloros ulfonylacetyl chloride affords these novel tricyclic heterocycles, which ar e novel and unpredicted products of this reaction. (C) 2001 Elsevier Scienc e Ltd. All rights reserved.