In vitro and in vivo inhibition of LPS-stimulated tumor necrosis factor-alpha secretion by the gallotannin beta-D-pentagalloylglucose

Authors
Feldman, KS Sahasrabudhe, K Lawlor, MD Wilson, SL Lang, CH Scheuchenzuber, WJ
Citation
Ks. Feldman et al., In vitro and in vivo inhibition of LPS-stimulated tumor necrosis factor-alpha secretion by the gallotannin beta-D-pentagalloylglucose, BIOORG MED, 11(14), 2001, pp. 1813-1815
Citations number
18
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
14
Year of publication
2001
Pages
1813 - 1815
Database
ISI
SICI code
0960-894X(20010723)11:14<1813:IVAIVI>2.0.ZU;2-S
Abstract
The naturally occurring gallotannin beta -D-pentagalloylglucose (beta -PGG) decreases tumor necrosis factor-alpha (TNF-alpha) output from human periph eral blood mononucleocytes exposed to lipopolysaccharide (LPS) by as much a s 90% (vs control) at similar to 5 muM concentration. A qualitatively simil ar but less pronounced effect (similar to 50% decrease) was observed in the serum of rats dosed with both LPS and beta -PGG. These results may have re levance to therapies that target disease states characterized by an overpro duction of TNF-alpha. (C) 2001 Elsevier Science Ltd. All rights reserved.