Nitrobenzene compounds inhibit expression of VCAM-1

Authors
Meng, CQ Zheng, XS Holt, LA Hoong, LK Somers, PK Hill, RR Saxena, U
Citation
Cq. Meng et al., Nitrobenzene compounds inhibit expression of VCAM-1, BIOORG MED, 11(14), 2001, pp. 1823-1827
Citations number
21
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
14
Year of publication
2001
Pages
1823 - 1827
Database
ISI
SICI code
0960-894X(20010723)11:14<1823:NCIEOV>2.0.ZU;2-C
Abstract
A series of nitrobenzene compounds has been discovered as potent inhibitors of VCAM-1 expression and, therefore, potential drug candidates for autoimm une and allergic inflammatory diseases. Structure-activity relationship (SA R) studies showed that a nitro group and two other electron-withdrawing gro ups are essential for these compounds to be potent inhibitors of VCAM-1 exp ression. (C) 2001 Elsevier Science Ltd. All rights reserved.