Synthesis of pyrrolo[1,2-a]quinoxaline derivatives by Lewis acid-catalyzedreactions of 1-(2-isocyanophenyl)pyrroles

Authors
Kobayashi, K Irisawa, S Matoba, T Matsumoto, T Yoneda, K Morikawa, O Konishi, H
Citation
K. Kobayashi et al., Synthesis of pyrrolo[1,2-a]quinoxaline derivatives by Lewis acid-catalyzedreactions of 1-(2-isocyanophenyl)pyrroles, B CHEM S J, 74(6), 2001, pp. 1109-1114
Citations number
38
Categorie Soggetti
Chemistry
Journal title
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN
ISSN journal
00092673 → ACNP
Volume
74
Issue
6
Year of publication
2001
Pages
1109 - 1114
Database
ISI
SICI code
0009-2673(200106)74:6<1109:SOPDBL>2.0.ZU;2-D
Abstract
1-(2-Isocyanophenyl)pyrroles have been prepared. They react in moderate to good isolated yields with aldehydes (or ketones), oxiranes, and acetals in the presence of catalytic amounts of diethyl ether-boron trifluoride to giv e pyrrolo[1,2-a]quinoxalines carrying an oxyalkyl substituent, such as alph a -hydroxyalkyl, beta -hydroxyalkyl, or alpha -alkoxyalkyl, at the 4-positi on.