Amm. Zumgottesberge et Jk. Mai, PRENATAL AND POSTNATAL EXPRESSION OF GLYCOCONJUGATES (3-FUCOSYL-N-ACETYLLACTOSAMINE AND HNK-1 EPITOPES) IN THE MOUSE INNER-EAR, International journal of developmental neuroscience, 15(4-5), 1997, pp. 645-656
The distribution of two glycoconjugates 3-fucosyl-N-acetyllactosamine
(CD15) and HNK-1 epitope (CD57) in the inner ear of the NMRI mouse was
analysed From the eighth day of gestation to the 16th day after birth
. CD15 epitope distribution is developmentally regulated. The up- and
down-regulation of expression, the change in the number of cells which
are positive, the ingrowth of CD15-positive cells and their distribut
ion, intracellular and/or cell-surface-associated expression, all assu
me a characteristic appearance at each developmental stage. Distributi
on of CD57 documented the nerve outgrowth and formation of the innerva
tion of the vestibular apparatus and cochlear duct. Correlation betwee
n CD15 and CD57 expression patterns revealed differences in the intera
ction of the ingrowing fibres and epithelial tissue between the vestib
ular organ and the cochlea and differences in the development of the c
ristae and maculae. (C) 1997 ISDN.