MOTIVATIONAL FACTORS IN COCAINE PHARMACOTHERAPY TRIALS WITH METHADONE-MAINTAINED PATIENTS - PROBLEMS AND PARADOXES

Pharmacotherapy trials for cocaine abuse among methadone-maintained pa tients have typically reported negative findings as well as high rates of cocaine use during the trial. The contribution of motivational fac tors to these results is a potentially important, underinvestigated ar ea. This article points out that some methadone-maintained patients ma y enter a trial for cocaine abuse with little desire for treatment, mo tivated primarily to continue receiving methadone or to avoid program sanctions for continued cocaine use. Participation in clinical trials may constitute a phase delaying discharge in a cyclic pattern of multi ple treatment episodes. Testing a pharmacologic agent in a motivationa lly inappropriate sample may not provide a good estimate of the agent' s effectiveness. In view of the important public health role that meth adone maintenance programs play in preventing HIV transmission, and th e subversion of this role by intravenous cocaine use, solutions to the se problems are urgently needed. The authors suggest several possible approaches, including pre- and posttreatment motivation assessment, as well as the inclusion of psychosocial interventions that provide the context for the emergence of potential medication effects.