Specifically targeting the CD22 receptor of human B-cell lymphomas with RNA damaging agents

Authors
Newton, DL Hansen, HJ Liu, HT Ruby, D Iordanov, MS Magun, BE Goldenberg, DM Rybak, SM
Citation
Dl. Newton et al., Specifically targeting the CD22 receptor of human B-cell lymphomas with RNA damaging agents, CR R ONC H, 39(1-2), 2001, pp. 79-86
Citations number
59
Categorie Soggetti
Oncology
Journal title
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
ISSN journal
10408428 → ACNP
Volume
39
Issue
1-2
Year of publication
2001
Pages
79 - 86
Database
ISI
SICI code
1040-8428(200107/08)39:1-2<79:STTCRO>2.0.ZU;2-6
Abstract
Targeting CD22 on human B-cells with a monoclonal antibody conjugated to a cytotoxic RNAse causes potent and specific killing of the lymphoma cells in vitro. This translates to anti-tumor effects in human lymphoma models in S CID mice. RNA damage caused by RNAses could be an important alternative to standard DNA damaging chemotherapeutics. Moreover, targeted RNAses may over come problems of toxicity and immunogenicity associated with plant or bacte rial toxin containing immunotoxins. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.