Refined localization of twenty-one genes in subregion p13.1 of human chromosome 1

In this report, we describe a refinement of the human transcript map of chr omosome 1p13.1, a subregion undergoing many aberrations in various types of human cancers. Publicly available genetic linkage, radiation hybrid and ph ysical maps. as well as cytogenetic and sequence data were used to establis h the relative order and orientation of ten known intragenic markers. The c omplete sequence of genomic clones of the region, available at the Sanger C entre, provided the tool fur further studies performed by BLAST analysis ag ainst all cDNA sequences registered in the Genexpress Index2. This allowed us to assign to subband 1p13.1 nine of the ten known genes, an additional m ember of the gene family of one of these genes and eleven new transcripts. The remaining known gene and one additional new transcript map at the 1p13. 1 and 1p13.2 boundary. The corresponding genes may be responsible for disor ders related to this region. The resulting transcript map of 1p13.1 is pres ented in the printed article with additional data available on a dedicated Web site at the address http://idefix.upr420.vjf.cnrs.fr/CARTO Copyright (C ) 2001 S. Karger AG, Basel.