Genomic organization and refined mapping of the human nuclear corepressor 2 (NCOR2)/silencing mediator of retinoid and thyroid hormone receptor (SMRT) gene on chromosome 12q24.3

The human nuclear co-repressor 2 (N-CoR2) gene (NCOR2, previously called si lencing mediator for retinoid and thyroid hormone receptor SMRT) is recruit ed to nuclear and non-nuclear receptors in a large repressing complex conta ining also N-CoR1, mSin3 and HDACs. This large complex represses transcript ion in absence of ligand. Herein we report the high-resolution and refined mapping of NCOR2 at the boundary of sub-bands 12q24.23 and 12q24.31, and it s intron/exon structure. The gene contains 45 exons. This information shoul d allow further study of potential NCOR2 genomic alteration in some subsets of malignancies. Copyright (C) 2001 S. Karger AG, Basel.