A two year global evaluation of the susceptibility of Candida species to fluconazole by disk diffusion

The in-vitro activity of fluconazole against 46,831 yeast isolates collecte d over a two-year period from 57 laboratories in 33 countries worldwide was assessed using a disc diffusion method. Candida albicans was the organism isolated most frequently, accounting for 68.6% of the total number of isola tes. C, glabrata, C, tropicalis, C parapsilosis and C. krusei and Cryptococ cus neoformans represented 9.9, 4.7, 4.3, 1.9, and 1.4% of isolates respect ively during the 2 year period and rates varied markedly between countries. In 1999 data blood isolates represented 4.9% of all isolates and intensive care unit isolates represented 9.9%, In both the 1998 and 1999 data, 99% o f C, albicans were fully susceptible (S) to fluconazole, and 95.6% of all s pecies of yeasts tested were S or susceptible-dose dependent (S-DD) to fluc onazole. No emerging trends of resistance were noted with any of the Candid a spp. tested as 96% of all isolates retained susceptibility (S or S-DD) to this agent. (C) 2001 Elsevier Science Inc. All rights reserved.