Ma. Glasby et al., IMMEDIATE AND DELAYED NERVE REPAIR USING FREEZE-THAWED MUSCLE AUTOGRAFTS IN COMPLEX NERVE INJURIES - CAVITATION, FIBROSIS AND HEMATOMA, Journal of hand surgery. British volume, 22B(4), 1997, pp. 479-485
Six sheep underwent repair of the median nerve along with the establis
hment of a cavity, fibrosis and haematoma at the site of injury. A fur
ther six sheep underwent similar repair delayed for 30 days after the
establishment of the complicating injury. Six months after the nerve r
epair each group of sheep was assessed using electrophysiological and
morphometric methods to establish objective indices of nerve recovery
and regeneration. These results were compared with sheep which had und
ergone both immediate and delayed nerve repair with no complicating in
jury. It was found that delay of the nerve repair and the presence of
a complicating injury, both alone and together, contributed to a poore
r outcome in recovery of nerve function and maturation.