Synthesis and characterization of poly(ethylene glycol)-block-poly(amino acid) copolymer

Authors
Yuan, ML Deng, XM
Citation
Ml. Yuan et Xm. Deng, Synthesis and characterization of poly(ethylene glycol)-block-poly(amino acid) copolymer, EUR POLYM J, 37(9), 2001, pp. 1907-1912
Citations number
14
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
EUROPEAN POLYMER JOURNAL
ISSN journal
00143057 → ACNP
Volume
37
Issue
9
Year of publication
2001
Pages
1907 - 1912
Database
ISI
SICI code
0014-3057(200109)37:9<1907:SACOPG>2.0.ZU;2-M
Abstract
Poly(ethylene glycol)(PEG) poly(amino acid) copolymer had been synthesized by using amino-terminated PEG as a primary amine. The mechanism is that the initiator amine undergoes a nucleophilic addition to the C-5 carbonyl grou p of the N-carboxyanhydride (NCA). The copolymerization improve the solubil ity of poly(amino acid) in organic solvents. Also, the hydrophilic/hydropho bic and soft/hard of the poly(amino acid) homopolymer can be modulated by c opolymerization of PEG with NCA. (C) 2001 Elsevier Science Ltd. All rights reserved.