The ATM-related domain of TRRAP is required for histone acetyltransferase recruitment and Myc-dependent oncogenesis

The ATM-related TRRAP protein is a component of several different histone a cetyltransferase (HAT) complexes but lacks the kinase activity characterist ic of other ATM family members. We identified a novel function for this evo lutionarily conserved domain in its requirement for the assembly of a funct ional HAT complex. Ectopic expression of TRRAP protein with a mutation in t he ATM-related domain inhibits Myc-mediated oncogenic transformation. The M yc-binding region of TRRAP maps to a separable domain, and ectopic expressi on of this domain inhibits cell growth. These findings demonstrate that the ATM-related domain of TRRAP forms a structural core for the assembly and r ecruitment of HAT complexes by transcriptional activators.