Sigmoid perforation following radiation therapy in patients with cervical cancer

Objective. We describe the clinical presentation, evaluation, management, a nd outcome of patients experiencing sigmoid perforation following radiation therapy for cervical cancer. Methods. A database consisting of over 5000 patients with stage IB-IIIB cer vix cancer treated between 1963 and 1992 revealed 35 patients with sigmoid perforation. Twenty-seven were diagnosed and managed at one institution, an d they form the study group. Results. The median age at the time of perforation was 50 years, and the me dian follow-up care was 78 months (range 6-396). The median time from compl etion of radiotherapy to perforation was 13 months (range 3-98). The mean i nterval from the first documented complaint to the index admission was 90 d ays. Nine (33%) of 27 patients were treated with high-dose radiation therap y. The most common complaint was abdominal pain in 25 (93%) patients, nause a occurred in 12 (44%) patients, weight loss in 12 (44%) patients, and vomi ting in 10 (37%) patients. The pain was described as mild in 16 (73%) of 22 patients. Only 5 (18.5%) of 27 patients had physical signs of acute perito nitis, 8 (30%) of 27 patients had some form of tenderness, and 11 (41%) of 27 had a benign exam. A total of 20 (74%) patients had an abdominal radiogr aph, and 12 (44%) patients had a contrast enema for evaluation. Evidence of perforation was present in 5 (25%) of 20 plain abdominal radiographs and 1 (8%) of 12 contrast enemas. Following admission, 17 (63%) patients were ob served initially with subsequent surgery after symptoms either failed to re solve or worsened. The median duration under observation was 4 days (range 1-23). Surgery was performed immediately in 8 patients (30%), and 2 (7%) we re observed without operation. In these 2 patients, perforation was diagnos ed postmortem. Seventeen (68%) of 25 patients had a localized abscess. Thre e of the patients who underwent immediate exploration and 7 who had surgery after a period of observation died postoperatively (10/25, 40%). Five (55% ) of 9 patients in the group who received high-dose radiation therapy died because of sigmoid perforation. When the time frame of presentation was eva luated, we noted that 10 (50%) of 20 patients died between 1960 and 1979 an d 1 (14%) of 7 died between 1980 and 1992. Conclusions. Sigmoid perforation following pelvic radiation for cervical ca ncer does not usually present with the typical signs of a ruptured viscus. A high degree of suspicion remains a priority in the care of radiated patie nts who present with abdominal pain given the atypical presentation of perf oration in this group. (C) 2001 Academic Press.