Clinical and histopathological signs of early Leser-Trelat-syndrome

Leser-Trelat-syndrome is characterized as the eruptive appearance of multip le seborrheic keratoses in association with underlying malignant disease. A 73 year old female patient with a metastatic adenocarcinoma of the colon p resented with this paraneoplastic change. The rapid appearance of solitary seborrheic keratoses with associated inflamation, seen clinically and histo logically, may be an early sign of Leser-Trelat-syndrome. The recognition o f this inflammatory component as an early sign may contribute to the prompt diagnosis of this paraneoplasia, even before the eruption of numerous sebo rrheic keratoses.