T-cell survival and the role of cytokines

Authors
Citation
J. Sprent, T-cell survival and the role of cytokines, IMM CELL B, 79(3), 2001, pp. 199-206
Citations number
47
Categorie Soggetti
Immunology
Journal title
IMMUNOLOGY AND CELL BIOLOGY
ISSN journal
08189641 → ACNP
Volume
79
Issue
3
Year of publication
2001
Pages
199 - 206
Database
ISI
SICI code
0818-9641(200106)79:3<199:TSATRO>2.0.ZU;2-C
Abstract
Typical T cells are long-lived resting cells. Despite their quiescent appea rance, there is increasing evidence that T cells are subjected to continuou s stimulation through contact with various stimuli, notably by self peptide /MHC complexes and cytokines. These stimuli keep T cells alive and also cau se intermittent entry into cell cycle.