The immunocompromised host's susceptibility to infections often present a d
ifficult diagnostic challenge to the physician. A working knowledge of the
host immune defenses and microbiologic complications that can occur when th
ese functions are compromised provides a more focused framework for further
evaluation and management. Infections in these patients are often morbid a
nd Life-threatening, creating an urgent need for prompt diagnosis. The skin
may manifest the first duets) of a serious underlying infection. Appropria
te workup and diagnosis of cutaneous lesions provide an expeditious, noninv
asive, and potentially life-saving approach to the immunocompromised host w
ith a dermatologic infection.