AUTOCRINE MOTILITY FACTOR-RECEPTOR EXPRESSION AS A PROGNOSTIC FACTOR IN PULMONARY ADENOCARCINOMA

Autocrine motility factor receptor (AMF-R) expression was studied immu nologically in tissue specimens from 121 patients with pulmonary adeno carcinoma. AMF-R expression was correlated with lymph node metastasis and stage. The prognosis of AMF-R positive patients was poorer than th at of AMF-R negative patients. Multivariate analysis showed that AMF-R expression had a significant influence on prognosis. Our findings sug gest that AMF-R plays an important role in tumor progression and that AMF-R expression is a useful prognostic marker for pulmonary adenocarc inomas.