Lobular carcinoma in situ and infiltrating ductal carcinoma: Frequent presence of DCIS as a precursor lesion

Authors
Maluf, H Koerner, F
Citation
H. Maluf et F. Koerner, Lobular carcinoma in situ and infiltrating ductal carcinoma: Frequent presence of DCIS as a precursor lesion, INT J SUR P, 9(2), 2001, pp. 127-131
Citations number
30
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology
Journal title
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
ISSN journal
10668969 → ACNP
Volume
9
Issue
2
Year of publication
2001
Pages
127 - 131
Database
ISI
SICI code
1066-8969(200104)9:2<127:LCISAI>2.0.ZU;2-9
Abstract
Infiltrating ductal carcinoma (IDC) occurs frequently in patients with lobu lar carcinoma in-situ (LCIS). LCIS is not thought to be the direct precurso r of the invasive component. The authors analyzed 15 cases of coexisting LC IS and IDC and found ductal carcinoma in situ (DCIS) in 12. The DCIS and ID C were of similar grade and located in the same area. Selected cases staine d with E-cadherin demonstrated a different immunophenotype for the lobular and ductal lesions. These results support the notion that DCIS is the direc t precursor of IDC occurring in patients with LCIS.