Leading patient safety proposals promote the design and implementation of e
rror prevention strategies that target systems used to deliver care and esc
hew individual blame, They also call for candor among practitioners about t
he causes and consequences of medical injury. Both goals collide with funda
mental tenets of the medical malpractice system. Thus, the challenge of add
ressing error in medicine demands a thorough reconsideration of the legal m
echanisms currently used to deal with harms in health care. In this article
, we describe an alternative to litigation that does not predicate compensa
tion on proof of practitioner fault, suggest how it might be operationalize
d, and argue that there is a pressing need to test its promise. We tackle t
raditional criticisms of "no-fault" compensation systems for medical injury
-specifically, concerns about their cost and the presumption that eliminati
ng liability will dilute incentives to deliver high-quality care. Our recen
t empirical work suggests that a model designed around avoidable or prevent
able injuries, as opposed to negligent ones, would not exceed the costs of
current malpractice systems in the United States. Implementation of such a
model promises to promote quality by harmonizing injury compensation with p
atient safety objectives, especially if it is linked to reforms that make i
nstitutions, rather than individuals, primarily answerable for injuries.