EFFECTS OF SHORT-TERM TREATMENT WITH THE ALPHA(1)-BLOCKER ALFUZOSIN ON URODYNAMIC PRESSURE-FLOW PARAMETERS IN PATIENTS WITH BENIGN PROSTATIC HYPERPLASIA

Objective: The objective of this double-blind, placebo-controlled urod ynamic pressure/flow study was to assess the efficacy of short-term tr eatment with the alpha(1)-blocker alfuzosin in outflow obstruction of patients with symptomatic benign prostatic hyperplasia (BPH). Material and Methods: Urodynamic pressure/flow parameters were assessed after 2 weeks of placebo run-in, 4 weeks of placebo (47 patients) or 2.5 mg t.i.d. alfuzosin treatment (47 patients), followed by an 8-week extens ion period with alfuzosin (single-blind). Results and Conclusion: Four weeks of alfuzosin treatment significantly increased maximum flow (+2 9.0%) and decreased detrusor pressure at maximum flow (-30.2%), detrus or opening pressure (-39.4%) and maximum detrusor pressure (-28.7%). S hort-term alfuzosin treatment improved outflow conditions in BPH by re ducing prostatic urethral obstruction.