S. Kawakami et al., PROGNOSTIC-SIGNIFICANCE OF PROSTATE-SPECIFIC ANTIGEN LEVELS 2 MONTHS AFTER HORMONAL MANIPULATION OF METASTATIC PROSTATE-CANCER, European urology, 32(1), 1997, pp. 58-63
Objective: To assess the prognostic significance of prostate-specific
antigen (PSA) levels before and during therapy in patients with metast
atic adenocarcinoma of the prostate receiving hormonal manipulation. M
ethods: The PSA levels before and during treatment, together with vari
ous clinicopathological parameters, were measured retrospectively in 4
8 patients with newly diagnosed metastatic prostate cancer. The progno
stic importance of these measurements was analyzed by both univariate
and multivariate techniques. Results: PSA levels 2 months after treatm
ent were the most useful predictors of progression-free (p = 0.004) or
cause-specific survival (p = 0.006) in a multivariate Cox proportiona
l-hazard model including histologic grade, age, performance status and
pretreatment hemoglobin. Conclusions: We have found that a low PSA le
vel 2 months after treatment is prognostically superior to conventiona
l clinicopathological parameters, such as histologic grade, in patient
s with metastatic prostate cancer undergoing treatment by hormonal man
ipulation.