A model of arterial adaptation to alterations in blood flow

Mechanisms of arterial adaptation to changes in blood flow rates were teste d by comparing the predictions of a proposed theoretical model with availab le experimental data. The artery was modeled as an elastic membrane made of a nonlinear, incompressible, elastic material. Stimulation of the vascular smooth muscle was modeled through the generation of an active component of circumferential stress. The muscular tone was modulated by flow-induced sh ear stress sensed by the arterial endothelium, and is responsible for the v asomotor adjustment of the deformed arterial diameter in response to change s in blood flow. This study addresses the hypothesis that the synthetic and proliferative activity of smooth muscle cells, leading to a change in arte rial dimensions, is shear stress dependent and is associated with changes i n the contractile state of the smooth muscle cells and changes in the circu mferential wall stress. Remodeling to a step change in flow was formulated as an initial-value problem for a system of first order autonomous differen tial equations for the evolution of muscular tone and evolution of arterial geometry. The governing equations were solved numerically for model parame ters identified from experimental data available in the literature. The mod el predictions for the time variation of the geometrical dimensions and the ir asymptotic values were found to be in qualitative agreement with availab le experimental data. Experiments for validating the introduced hypotheses and further generalizations of the model were discussed.