Fluorine substituent effects (on bioactivity)

Authors
Smart, BE
Citation
Be. Smart, Fluorine substituent effects (on bioactivity), J FLUORINE, 109(1), 2001, pp. 3-11
Citations number
31
Categorie Soggetti
Inorganic & Nuclear Chemistry
Journal title
JOURNAL OF FLUORINE CHEMISTRY
ISSN journal
00221139 → ACNP
Volume
109
Issue
1
Year of publication
2001
Pages
3 - 11
Database
ISI
SICI code
0022-1139(200106)109:1<3:FSE(B>2.0.ZU;2-2
Abstract
The characteristic effects of fluorine and fluoroalkyl substituents on the physico-chemical properties of molecules that are important to biological a ctivity of fluorinated compounds are highlighted. The influence of fluorina tion on acidity, hydrogen-bonding, and lipophilicity that affect compound a bsorption and distribution is described. The current perspectives on fluori ne steric interactions and the controversial role of hydrogen-bonding invol ving the C-F bond are discussed. (C) 2001 Elsevier Science B.V. All rights reserved.