New fluorine-containing hypotensive preparations

The synthesis and pharmacological properties of a novel type of vasorelaxan t hybrid compounds are described. The investigated compounds are based on f luorinated 4-aryl-1,4-dihydropyridines (1,4-DHP), which are known calcium c hannel blockers, and/or from fluorinated analogues of pinacidil, an opener of ATP-sensitive potassium channels. Benzimidazole analogues of hypotensive preparation losartan with fluorine-containing substituents in positions 2 and 5, as well as at heterocyclic nitrogen atom of benzimidazole ring are d iscussed. (C) 2001 Elsevier Science B.V. All rights reserved.