Identifying sex chromosome abnormalities in forensic DNA testing using amelogenin and sex chromosome short tandem repeats

Forensic DNA laboratories worldwide have begun using multiplexed STR system s to decrease analysis time and increase sample throughput. The loci used i n these systems are basically "nonsense" regions of human DNA. However, due to the chromosome on which some of these loci are located, various genetic abnormalities can sometimes be detected. This paper will show one such abn ormality-Klinefelter's Syndrome-and the process used to show the possibilit y of this defect in two undiagnosed males using peak height ratios at the A melogenin locus, and X-Y STRs.