DNA typing results from two urban subpopulations of Pakistan

A population genetic characterization of the Araeen and Raajpoot ethnic sub populations of Lahore City, Pakistan was undertaken in order to assess the utility of DNA typing for forensic purposes in Pakistani populations. One h undred unrelated individuals from each group were genotyped for four indepe ndently assorting loci: HLA DQA1, CSF1PO, TPOX, and TH01. Allele frequencie s were calculated, one- and two-locus tests for association were conducted, and the samples were compared by contingency table rests and F-statistic e stimation. Although there is expected to be some genetic divergence between the two groups, forensic needs may be satisfied with a single Pakistani da tabase of DNA profiles. The present data suggest that nine independently as serting loci will be sufficient to provide estimated profile probabilities of the order of 10(-9) but a set of 13 loci, as employed in the U.S., would better compensate for the dependencies introduced by family membership and evolutionary history.