A randomized comparison of triple therapy Helicobacter pylori eradication regimens in children with peptic ulcers

Citation
Pl. Shcherbakov et al., A randomized comparison of triple therapy Helicobacter pylori eradication regimens in children with peptic ulcers, J INT MED R, 29(3), 2001, pp. 147-153
Citations number
19
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Medical Research General Topics
Journal title
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
ISSN journal
03000605 → ACNP
Volume
29
Issue
3
Year of publication
2001
Pages
147 - 153
Database
ISI
SICI code
0300-0605(200105/06)29:3<147:ARCOTT>2.0.ZU;2-6
Abstract
An open, randomized trial was performed to compare the efficacy of three He licobacter pylori eradication regimens in children with peptic ulcer diseas e. A total of 106 children (5 - 15 years) were treated for 1 week with metr onidazole, 30 - 40 mg/kg per day depending on age, amoxycillin, 750 mg/day, and one of three anti-secretory agents: proprietary omeprazole, 20 - 40 mg /day depending on age; generic omeprazole, 20 - 40 mg/day; or ranitidine, 1 50 mg twice daily. The H. pylori eradication rate was significantly higher in patients receiving proprietary omeprazole (88.9%) than in those receivin g generic omeprazole (80.0%) or ranitidine (74.3%), and this was associated with a trend towards faster ulcer healing. It is concluded that triple the rapy consisting of an anti-secretory agent and two antimicrobials produces effective eradication of H. pylori and ulcer healing in children with pepti c ulcer disease, and that proprietary omeprazole is more effective than bot h ranitidine and the generic formulation used in this study.