Absence of human herpesvirus-6 genome by polymerase chain reaction in children with Hodgkin disease: A Children's Cancer Group Lymphoma Biology study

Authors
Shiramizu, B Chang, CW Cairo, MS
Citation
B. Shiramizu et al., Absence of human herpesvirus-6 genome by polymerase chain reaction in children with Hodgkin disease: A Children's Cancer Group Lymphoma Biology study, J PED H ONC, 23(5), 2001, pp. 282-285
Citations number
20
Categorie Soggetti
Pediatrics
Journal title
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
ISSN journal
10774114 → ACNP
Volume
23
Issue
5
Year of publication
2001
Pages
282 - 285
Database
ISI
SICI code
1077-4114(200106/07)23:5<282:AOHHGB>2.0.ZU;2-1
Abstract
Background: Human herpesvirus-6 (HHV6) has been implicated in adult lymphom as but the role that HHV6 has in lymphomagenesis is unclear. Because primar y infection occurs in children, a prospective study was undertaken to detec t HHV6 in those with pediatric Hodgkin disease (HD). Observations: Tumor was obtained from children with HD entered on a Childre n's Cancer Group Biology Study. Polymerase chain reaction (PCR) was perform ed using HHV6 primers. All 47 specimens (40 nodular sclerosing; 3 lymphocyt e predominant: 3 mixed cellularity; and 1 unclassified) were negative for H HV6. Conclusions: The results demonstrate no HHV6 sequence in childhood HD.