Rapid quantification of iodopropynyl butylcarbamate as the preservative incosmetic formulations using high-performance liquid chromatography-electrospray mass spectrometry

A simple, rapid and reproducible method for identification and quantificati on of iodopropynyl butylcarbamate (IPBC) in different cosmetic formulations is presented. The determination was carried out using a high-performance l iquid chromatography (HPLC) procedure on a reversed phase column coupled to a single quadrupole mass spectrometer (MS) via an electrospray ionization (ESI) interface. Detection was performed in the positive selected ion-monit oring mode. In methanol/water extracts from different cosmetic formulations a detection limit between 50 and 100 ng/g could be achieved. A routine ana lytical procedure could be set up with good quantification reliability (rel ative standard deviation between 0.9 and 2.9%). (C) 2001 Elsevier Science B .V. All rights reserved.