Synthesis of 3-(2 ',3 ',4 '-trimethoxyphenyl)isocoumarin and its dihydro-derivative

Authors
Ahmad, BUD Malana, MA Rama, NH Hussain, MT
Citation
Bud. Ahmad et al., Synthesis of 3-(2 ',3 ',4 '-trimethoxyphenyl)isocoumarin and its dihydro-derivative, J CHEM S P, 22(2), 2000, pp. 151-154
Citations number
13
Categorie Soggetti
Chemistry
Journal title
JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN
ISSN journal
02535106 → ACNP
Volume
22
Issue
2
Year of publication
2000
Pages
151 - 154
Database
ISI
SICI code
0253-5106(200006)22:2<151:SO3'''>2.0.ZU;2-L
Abstract
3-(2 ' ,3 ' ,4 ' -Trimethoxyphenyl)isocourmarin (7) was synthesized by the condensation of homophthalic acid (5) with 2,3,4-trimethoxybenzoyl chloride (6) which on alkine hydrolysis gave the keto-acid (8). (dl)-3-(2 ' ,3 ' ,4 ' -Trimethoxyphenyl)-3,4-dihydroisocoumarin (11) was obtained by reduction of the keto-acid (8) to racemic hydroxy-acid (10) followed by cyclodehydra tion using acetic anhydride.