Linezolid resistance in a clinical isolate of Staphylococcus aureus

Authors
Tsiodras, S Gold, HS Sakoulas, G Eliopoulos, GM Wennersten, C Venkataraman, L Moellering, RC Ferraro, MJ
Citation
S. Tsiodras et al., Linezolid resistance in a clinical isolate of Staphylococcus aureus, LANCET, 358(9277), 2001, pp. 207-208
Citations number
5
Categorie Soggetti
General & Internal Medicine","Medical Research General Topics
Journal title
LANCET
ISSN journal
01406736 → ACNP
Volume
358
Issue
9277
Year of publication
2001
Pages
207 - 208
Database
ISI
SICI code
0140-6736(20010721)358:9277<207:LRIACI>2.0.ZU;2-Z
Abstract
The new oxazolidinone antimicrobial, linezolid, has been approved for the t reatment of infections caused by various gram-positive bacteria, including meticillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE). Although instances of linezolid resistance in VRE have b een reported, resistance has not been encountered among clinical isolates o f S aureus. We have characterised an MRSA isolate resistant to linezolid th at was recovered from a patient treated with this agent for dialysis-associ ated peritonitis.