Cold feet and prolonged sleep-onset latency in vasospastic syndrome

People with vasospastic syndrome have cold hands and feet and abnormal vaso constriction after local cold exposure. Normally there is a circadian rhyth m of distal vasodilation, with onset in the early evening, which directly i nfluences ability to fall asleep. We gave a sleep questionnaire to 32 patie nts with primary vasospastic syndrome and 31 healthy controls. People with vasospasticity had significantly prolonged sleep-onset latency both at onse t of night-time sleep and after nocturnal disturbance. This prolonged laten cy could be associated with impaired capacity for distal vasodilation.