Diversion of key cellular functions by bacterial pathogens

Bacterial pathogens interact with various host cell components to establish and develop an infectious process. Soma bacteria are able to invade cells that are normally nonphagocytic, to multiply freely within the cell cytosol , and to disseminate from cell to cell using actin based motility. Other ba cterial pathogens multiply extracellularly and are able to prevent their in ternalization by phagocytic cells. Finally, some bacteria are able to persi st and to multiply within intracellular vacuole in the macrophage, by diver ting the cell endosomal trafficking. In this review, we will focus on bacte rial models that have been particularly studied and that illustrate these v arious cellular strategies.