Exercise in chronic pulmonary disease resistance exercise prescription, Med
. Sci. Sports Exerc. Vol. 33. No. 7, Suppl., pp. S680-S686, 2001. Resistanc
e exercise training has received relatively little attention as a means to
reduce the muscle dysfunction and ensuing exercise intolerance seen in chro
nic pulmonary diseases. To date, only a few studies have examined the chara
cteristics of skeletal muscle function or its responsiveness to strength tr
aining in patients with chronic respiratory diseases. It is clear from thes
e studies, however, that peripheral muscle, particularly muscles of ambulat
ion, are weak in patients with lung disease, exhibiting effort-dependent st
rength scores that are 70-80%; of these measures in age-matched healthy sub
jects. The degree to which this dysfunction is accounted for by decondition
ing, disease-related myopathy, or other causes is unclear. It is evident, h
owever, that patients with chronic respiratory diseases can acquire and mai
ntain substantial improvements in skeletal muscle function, physical functi
on, and quality of life through participation in a well-structured program
of resistance exercise training. Despite the positive. albeit limited, evid
ence that skeletal muscle dysfunction may be improved with resistance train
ing, no clear guidelines are available for this purpose. This review discus
ses the skeletal muscle dysfunction that accompanies chronic respiratory di
sease and presents strategies for resistance exercise training that mag. he
considered as part of pulmonary rehabilitation. These strategies are deriv
ed from the successful outcomes noted in studies using resistance training
in patients with COPD as well as on extrapolations from extant guidelines u
sed to develop strength, power, and endurance in healthy individuals.