The choice of the sample preparation method is crucial in chemical analysis
, since it is often the most critical and time-consuming step of an analyti
cal process. Some of the older methods are laborious, expensive, and offer
no scope for automation. The newer sample preparation techniques can give h
igher yields, better sample clean-up, cost effectiveness worker safety and
environmental protection. Some novel sample preparation methods are describ
ed their potential is illustrated with emphasis on bioanalytical applicatio
ns.