Early expressed Clb proteins allow accumulation of mitotic cyclin by inactivating proteolytic machinery during S phase

Authors
Yeong, FM Lim, HH Wang, Y Surana, U
Citation
Fm. Yeong et al., Early expressed Clb proteins allow accumulation of mitotic cyclin by inactivating proteolytic machinery during S phase, MOL CELL B, 21(15), 2001, pp. 5071-5081
Citations number
26
Categorie Soggetti
Molecular Biology & Genetics
Journal title
MOLECULAR AND CELLULAR BIOLOGY
ISSN journal
02707306 → ACNP
Volume
21
Issue
15
Year of publication
2001
Pages
5071 - 5081
Database
ISI
SICI code
0270-7306(200108)21:15<5071:EECPAA>2.0.ZU;2-7
Abstract
Periodic accumulation and destruction of mitotic cyclins are important for the initiation and termination of M phase. It is known that both APC(Cdc20) and APC(Hct1) collaborate to destroy mitotic cyclins during M phase. Here we show that this relationship between anaphase-promoting complex (APC) and Clb proteins is reversed in S phase such that the early Clb kinases (Clb3, Clb4, and Clb5 kinases) inactivate APC(Hct1) to allow Clb2 accumulation. T his alternating antagonism between APC and Clb proteins during S and M phas es constitutes an oscillatory system that generates undulations in the leve ls of mitotic cyclins.